Latin America and the Caribbean is one of the most urbanised regions of the planet. At the same time it is also the world’s most unequal region, a region where poverty and wealth coexist and antagonise each other daily, especially in urban spaces. Today, 80 per cent of the Latin American population lives in cities, with half of the urban population in LAC concentrated in rapidly growing intermediate cities. But what are the main challenges cities in Latin America and the Caribbean have to face? And which integral approaches do cities pursue to overcome them?